Argireline

A cosmetic hexapeptide derived from SNAP-25, marketed for wrinkle reduction.

What research shows

Argireline has more evidence behind it than most cosmetic peptides: controlled studies measuring wrinkle endpoints, a pilot clinical study, and inclusion in a systematic review of topical peptides for skin ageing. The effects measured are modest and cosmetic rather than clinical in nature.

Evidence strength

Highest evidence grade among the graded claims: A. Grades reflect study strength, not benefit.

Safety context

See the safety section. Absence of a flag is not evidence of safety.

No endorsement

A grade reflects evidence strength, not a recommendation to use this compound; a strong grade can attach to a harmful effect.