MK-677 has more human data than most compounds sold in this space: randomized trials show it raises growth hormone and IGF-1 markers, and a two-year trial found increased fat-free mass in older adults. A separate trial in Alzheimer disease found no clinical benefit.

MK-677

MK-677 has more human data than most compounds sold in this space: randomized trials show it raises growth hormone and IGF-1 markers, and a...

About:

An orally active non-peptide growth hormone secretagogue studied in human trials for effects on GH and IGF-1.

Growth HormoneCapsules or research liquid

What does this peptide do?

Backed by human trial data, narrower than the strongest evidence. Research focuses on growth hormone and IGF-1.

Growth hormone

Randomised trials report raised growth hormone markers.

IGF-1

Trials also report raised IGF-1 markers.

Evidence grade

Highest evidence grade among the graded claims: B. Grades reflect study strength, not benefit.

What are the benefits and side effects of this peptide

What research says it may help with

MK-677 has more human data than most compounds sold in this space: randomized trials show it raises growth hormone and IGF-1 markers, and a two-year trial found increased fat-free mass in older adults.

Who should avoid it

People who are pregnant or breastfeeding
Children and adolescents
People with diabetes or impaired glucose tolerance, since secretagogues affect blood sugar
People with heart failure
Known hypersensitivity to peptide preparations

See the safety section. Absence of a flag is not evidence of safety.

A grade reflects evidence strength, not a recommendation to use this compound; a strong grade can attach to a harmful effect.