MK-677

An orally active non-peptide growth hormone secretagogue studied in human trials for effects on GH and IGF-1.

What research shows

MK-677 has more human data than most compounds sold in this space: randomized trials show it raises growth hormone and IGF-1 markers, and a two-year trial found increased fat-free mass in older adults. A separate trial in Alzheimer disease found no clinical benefit.

Evidence strength

Highest evidence grade among the graded claims: B. Grades reflect study strength, not benefit.

Safety context

See the safety section. Absence of a flag is not evidence of safety.

No endorsement

A grade reflects evidence strength, not a recommendation to use this compound; a strong grade can attach to a harmful effect.