KPV

The C-terminal tripeptide of alpha-MSH, studied for anti-inflammatory activity mainly in animal and cell models.

What research shows

All verified evidence is preclinical: KPV reduced intestinal inflammation in mouse models of colitis, entered cells through the PepT1 transporter in laboratory work, and belongs to the anti-inflammatory melanocortin family as the C-terminal fragment of alpha-MSH. No human trial of KPV was verified, and human dosing and safety data are absent.

Evidence strength

Highest evidence grade among the graded claims: D. Grades reflect study strength, not benefit.

Safety context

See the safety section. Absence of a flag is not evidence of safety.

No endorsement

A grade reflects evidence strength, not a recommendation to use this compound; a strong grade can attach to a harmful effect.