
TB-500
Thymosin beta-4 fragment explored for flexibility and tissue repair.
About:
TB-500 is a synthetic fragment of thymosin beta-4, a protein involved in cell migration and tissue building. It is explored in recovery research for its potential effects on flexibility and repair.
What does this peptide do?
Researchers study its role in actin regulation, angiogenesis, and tendon recovery, frequently comparing its profile to other recovery-focused peptides such as BPC-157.

Flexibility
Explored for range of movement in recovery research.

Tissue repair
Studied for actin regulation and tendon recovery.
Evidence grade
CHighest evidence grade among the graded claims: C. Grades reflect study strength, not benefit.
What are the benefits and side effects of this peptide
What research says it may help with
- It is explored in recovery research for its potential effects on flexibility and repair.
- Research focus: Flexibility & Tissue Repair Researchers study its role in actin regulation, angiogenesis, and tendon recovery, frequently comparing its profile to other recovery-focused peptides such as BPC-157.
- TB-500 sits on the World Anti-Doping Agency prohibited list, and no randomized controlled trial data in humans has been published.
Who should avoid it
- People who are pregnant or breastfeeding
- Children and adolescents
- People with a personal or family history of cancer
- Competitive athletes subject to anti-doping testing, since TB-500 is a banned substance
- Active or suspected malignancy, since studied mechanisms involve angiogenesis and cell proliferation
See the safety section. Absence of a flag is not evidence of safety.
A grade reflects evidence strength, not a recommendation to use this compound; a strong grade can attach to a harmful effect.

How to store this peptide
Typically supplied as a lyophilized peptide requiring refrigeration or freezing before reconstitution, with the reconstituted solution kept refrigerated and used within a limited window. Products from unregulated compounding or research-chemical sources have not been evaluated for sterility or purity.
Lyophilized storage
Store at −20 °C, protected from light.
Reconstituted storage
Keep at 2–8 °C and use within a short period. For longer storage, aliquot and freeze at −20 °C.
Storage Handling
Avoid repeated freeze–thaw cycles. Let the vial reach room temperature before opening.


